CGRP-targeting antibodies reduce migraine frequency

CGRP antagonists and antibodies for the treatment of migraine.

Introduction: Migraine is a highly devastating neurovascular disorder that affects up to 16% of the population worldwide. In spite of intensive research, its origin remains enigmatic with no therapeutic option appropriate for all migraine patients. One of the leading hypotheses is related to the function of the calcitonin gene-related peptide (CGRP). Regardless, the pharmaceutical options curre...

Anti-CGRP Monoclonal Antibodies: the Next Era of Migraine Prevention?

OPINION STATEMENT Migraine is a very disabling disorder with severe impact on patients' lives and substantive costs to society in terms of healthcare costs and lost productivity. Prevention is a key component of migraine therapy, and while numerous preventive options exist, each is burdened by either troublesome side effects or insufficient efficacy. All migraine preventives currently in clinic...

Anti-CGRP antibodies: a new approach to migraine prevention.

CGRP antibodies: the Holy Grail for migraine prevention?

Serotonin and CGRP in Migraine

Migraine is defined as recurrent attack of headache that are commonly unilateral and accompanied by gastrointestinal and visual disorders. Migraine is more prevalent in females than males with a ratio of 3:1. It is primarily a complex neurovascular disorder involving local vasodilation of intracranial, extracerebral blood vessels and simultaneous stimulation of surrounding trigeminal sensory ne...